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The Mollicute repository

Mycoplasma composite image

Mollicutes are ubiquitous in nature and many species within this bacterial class are of economical, clinical and veterinary relevance.

NCTC has a fully curated Mollicute collection which consists of over 126 strains of medical and veterinary importance from the following genus: Acholeplasma (9 strains); Entomoplasma (5 Strains); Mesoplasma (3 strains); Mycoplasma (97 strains) and Ureaplasma (10 strains). The NCTC mollicute collection is a fundamental part of the NCTC catalogue with the first strains having been provided to NCTC by Professor Eyvind Antonius Freundt who was a pioneer of Mycoplasma science. The current NCTC mollicute collection is made up of 121 different species of which 107 are type strains. All strains are preserved lyophilised within glass ampoules and are shipped globally. The mollicute collection have traditionally been quality controlled using immunological methods but recently both next generation sequencing technologies and in some cases MALDI-TOF MS analysis have been introduced, to authenticate strain banks.

It is recognised that existence of the NCTC mollicute collection has contributed significantly to Mycoplasma research. The provision of well catalogued stocks to define the taxonomy, phylogeny and identification of human and animal mollicutes has been crucial for diagnostic and vaccine development, detection of pharmaceutical product contamination and studies on antibiotic resistance. NCTC is also an internationally recognised repository for bacterial type strains deposits has also played a supportive role in the the description of new mycoplasma species such as Mycoplasma amphoriforme (NCTC 11740T) and Mycoplasma iguanae (NCTC 11745).

NCTC is a dynamic bacterial collection and an active repository for newly described and clinically relevant bacterial strains. Scientists working on Mollicutes which are of either medical or veterinary significance are encouraged to deposit strains into the collection to promote both scientific accessibility and reproducibility.


Written by Dr Sarah Alexander and Dr Vicki Chalker

April 2020