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European Bank for induced pluripotent Stem Cells (EBiSC) Publications

EBiSC2

 

The European Bank for induced pluripotent Stem Cells (EBiSC) launched a second project phase in 2019 to become a self-sustainable repository for human induced pluripotent stem cells (hiPSC), extend the existing cell catalogue, and offer additional hiPSC-related services.

Several articles have subsequently been published on topics such as the generation of isogenic, gene-edited iPSC lines in Alzheimer's disease research, the Human Pluripotent Stem Cell Registry (hPSCreg) and its role in registration of pluripotent cell lines and EBiSC as a cell line bank for disease studies:

  

Wiley

 

Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype: Genome-wide association studies demonstrated that polymorphisms in the CD33/sialic acid-binding immunoglobulin-like lectin 3 gene are associated with late-onset Alzheimer's disease (AD). CD33 is expressed on myeloid immune cells and mediates inhibitory signaling through protein tyrosine phosphatases, but the exact function of CD33 in microglia is still unknown... 

 

Stem Cell Research 52

 

Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus: Neurog2 is the gene encoding the neuronal transcription factor NGN2, which can convert stem cells into functional neurons in a fast and efficient way. Here we report the generation of two iPS cell lines, where DOX inducible constructs of neurog2 either without or with T2A-eGFP were inserted into the safe-site locus AAVS1... 

 

 

Stem Cell Research 52

 

Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line Alzheimer's disease (AD) is the most frequent neurodegenerative disease amongst the elderly. The SNPs rs429358 and rs7412 in the APOE gene are the most common risk factor for sporadic AD, and there are three different alleles commonly referred to as APOE-ε2, APOE-ε3 and APOE-ε4. Induced pluripotent stem cells (iPSCs) hold great promise to model AD as such cells can be differentiated in vitro to the required cell type....

  

Stem Cell Research 2

 

The EBiSC iPSC bank for disease studies: The European Bank for induced Pluripotent Stem Cells (EBiSC), a non-profit repository for storage, banking, Quality Control (QC) and subsequent distribution of research-grade human induced Pluripotent Stem Cell (iPSC) lines, has centralised iPSC lines generated internationally across >35 disease areas and made them available to users via the EBiSC Catalogue, for research use (cells.ebisc.org/).... 

  

  

Stem Cell Research 3

 

Access to stem cell data and registration of pluripotent cell lines: The Human Pluripotent Stem Cell Registry (hPSCreg) The value of human pluripotent stem cells (hPSC) in regenerative medicine has yet to reach its full potential. The road from basic research tool to clinically validated PSC-derived cell therapy products is a long and winding one, leading researchers, clinicians, industry and regulators alike into undiscovered territory.....

 

 

 

Jannis Wißfeld et al., Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype, GLIA Volume 69, Issue 6, June 2021, Pages 1393-1412 https://doi.org/10.1002/glia.23968

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